Position
Research Director (DR) CNRS
Team "Cytokines, Evolution and Onset of Immunity"
Contact
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: +33 (0)4 67 14 47 75
Biographie
*** coming soon ***
Publications
Pagani I, Di Pietro A, Oteiza A, Ghitti M, Mechti N, Naffakh N, Vicenzi E (2018) Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009. mSphere 3:e00110-18. doi:10.1128/mSphere.00110-18
Oteiza A, Mechti N (2017) FoxO4 negatively controls Tat-mediated HIV-1 transcription through the post-transcriptional suppression of Tat encoding mRNA. J Gen Virol 98:1864-1878. doi:10.1099/jgv.0.000837
Oteiza A, Mechti N (2015) Control of FoxO4 Activity and Cell Survival by TRIM22 Directs TLR3-Stimulated Cells Toward IFN Type I Gene Induction or Apoptosis. J Interferon Cytokine Res 35:859-874. doi:10.1089/jir.2015.0020
Liu Y, Nie H, Mao R, Mitra B, Cai D, Yan R, Guo JT, Block TM, Mechti N, Guo H (2017) Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA. PLoS Pathog 13:e1006296. doi:10.1371/journal.ppat.1006296
Di Pietro A, Kajaste-Rudnitski A, Oteiza A, Nicora L, Towers GJ, Mechti N, Vicenzi E (2013) TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation. J Virol 87:4523-4533. doi:10.1128/JVI.02548-12
Imaizumi T, Tanaka H, Mechti N, Matsumiya T, Yoshida H, Sato F, Aizawa-Yashiro T, Tsuruga K, Hayakari R, Satoh K (2011) Polyinosinic-polycytidylic acid induces the expression of interferon-stimulated gene 20 in mesangial cells. Nephron Exp Nephrol 119:e40-48. doi:10.1159/000328923
Oteiza A, Mechti N (2011) The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome. J Virol 85:6480-6491. doi:10.1128/JVI.00036-11
Kajaste-Rudnitski A, Marelli SS, Pultrone C, Pertel T, Uchil PD, Mechti N, Mothes W, Poli G, Luban J, Vicenzi E (2011) TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements. J Virol 85:5183-5196. doi:10.1128/JVI.02302-10
Papon L, Oteiza A, Imaizumi T, Kato H, Brocchi E, Lawson TG, Akira S, Mechti N (2009) The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection. Virology 393:311-318. doi:10.1016/j.virol.2009.08.009
Eldin P, Papon L, Oteiza A, Brocchi E, Lawson TG, Mechti N (2009) TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus. J Gen Virol 90:536-545. doi:10.1099/vir.0.006288-0
Taylor KL, Leaman DW, Grane R, Mechti N, Borden EC, Lindner DJ (2008) Identification of interferon-beta-stimulated genes that inhibit angiogenesis in vitro. J Interferon Cytokine Res 28:733-740. doi:10.1089/jir.2008.0030
Imaizumi T, Mechti N, Matsumiya T, Sakaki H, Kubota K, Yoshida H, Kimura H, Satoh K (2008) Expression of interferon-stimulated gene 20 in vascular endothelial cells. Microbiol Immunol 52:30-35. doi:10.1111/j.1348-0421.2008.00004.x
Obad S, Olofsson T, Mechti N, Gullberg U, Drott K (2007) Regulation of the interferon-inducible p53 target gene TRIM22 (Staf50) in human T lymphocyte activation. J Interferon Cytokine Res 27:857-864. doi:10.1089/jir.2006.0180
Maurice T, Duclot F, Meunier J, Naert G, Givalois L, Meffre J, Célérier A, Jacquet C, Copois V, Mechti N, Ozato K, Gongora C (2008) Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice. Neuropsychopharmacology 33:1584-1602. doi:10.1038/sj.npp.1301551
Degols G, Eldin P, Mechti N (2007) ISG20, an actor of the innate immune response. Biochimie 89:831-835. doi:10.1016/j.biochi.2007.03.006
Vendrell JA, Ghayad S, Ben-Larbi S, Dumontet C, Mechti N, Cohen PA (2007) A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells. Oncogene 26:4656-4667. doi:10.1038/sj.onc.1210269
Obad S, Olofsson T, Mechti N, Gullberg U, Drott K (2007) Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow. Leuk Res 31:995-1001. doi:10.1016/j.leukres.2006.12.012
Espert L, Eldin P, Gongora C, Bayard B, Harper F, Chelbi-Alix MK, Bertrand E, Degols G, Mechti N (2006) The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes. J Cell Biochem 98:1320-1333. doi:10.1002/jcb.20869
Espert L, Degols G, Lin YL, Vincent T, Benkirane M, Mechti N (2005) Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1. J Gen Virol 86:2221-2229. doi:10.1099/vir.0.81074-0
Vincent T, Mechti N (2005) Extracellular matrix in bone marrow can mediate drug resistance in myeloma. Leuk Lymphoma 46:803-811. Review. doi:10.1080/10428190500051448
