Maryse Lebrun Group:
Suarez C, Lentini G, Ramaswamy R, Maynadier M, Aquilini E, Berry-Sterkers L, Cipriano M, Chen AL, Bradley P, Striepen B, Boulanger MJ, Lebrun M. A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites. Nat Commun. 2019 Sep 6;10(1):4041.
Berry L, Chen CT, Francia ME, Guerin A, Graindorge A, Saliou JM, Grandmougin M, Wein S, Bechara C, Morlon-Guyot J, Bordat Y, Gubbels MJ, Lebrun M, Dubremetz JF, Daher W. Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny. Cell Mol Life Sci, (2018) Jul 26.
Morlon-Guyot J, El Hajj H, Martin K, Fois A, Carrillo A, Berry L, Burchmore R, Meissner M, Lebrun M, Daher W. A proteomic analysis unravels novel CORVET and HOPS proteins involved in Toxoplasma gondii secretory organelles biogenesis. Cell Microbiol, (2018) 17:e12870.
Wengelnik K, Daher W, Lebrun M. Phosphoinositides and their functions in apicomplexan parasites. Int J Parasitol. (2018) Jun;48(7):493-504.
Lebrun M, Blanchard N. Host-microbe interactions: parasites. Volume 40 December 2017
Guérin A, El Hajj H, Penarete-Vargas D, Besteiro S, Lebrun M. RON4(L1) is a new member of the moving junction complex in Toxoplasma gondii. Sci Rep, (2017) Dec 20;7(1):17907.
Lentini G, El Hajj H, Papoin J, Fall G, Pfaff AW, Tawil N, Braun-Breton C, Lebrun M. Characterization of Toxoplasma DegP, a rhoptry serine protease crucial for lethal infection in mice. PLoS One, (2017) Dec 15;12(12):e0189556.
Frénal K, Dubremetz JF, Lebrun M, Soldati-Favre D. Gliding motility powers invasion and egress in Apicomplexa. Nat Rev Microbiol, (2017) Nov;15(11):645-660.
Guérin A, Corrales RM, Parker ML, Lamarque MH, Jacot D, El Hajj H, Soldati-Favre D, Boulanger MJ, Lebrun M. Efficient invasion by Toxoplasma depends on the subversion of host protein networks. Nat Microbiol, (2017) Oct;2(10):1358-1366.
Miliu A, Lebrun M, Braun-Breton C, Lamarque MH. Shelph2, a bacterial-like phosphatase of the malaria parasite Plasmodium falciparum, is dispensable during asexual blood stage. PLoS One, (2017) Oct 26;12(10):e0187073.
Nguyen HM, El Hajj H, El Hajj R, Tawil N, Berry L, Lebrun M, Bordat Y, Besteiro S. Toxoplasma gondii autophagy-related protein ATG9 is crucial for the survival of parasites in their host. Cell Microbiol, (2016) Jun (19) 6.
Berry L, Chen CT, Reininger L, Carvalho TG, El Hajj H, Morlon-Guyot J, Bordat Y, Lebrun M, Gubbels MJ, Doerig C, Daher W. The conserved apicomplexan Aurora kinase TgArk3 is involved in endodyogeny, duplication rate and parasite virulence. Cell Microbiol, (2016) Aug;18(8):1106-20.
Daher W, Morlon-Guyot J, Alayi TD, Tomavo S, Wengelnik K, Lebrun M. Identification of Toxoplasma TgPH1, a pleckstrin homology domain-containing protein that binds to the phosphoinositide PI(3,5)P2. Mol Biochem Parasitol, (2016) May;207(1):39-44.
Parker ML, Penarete-Vargas DM, Hamilton PT, Guérin A, Dubey JP, Perlman SJ, Spano F, Lebrun M*, Boulanger MJ*. Dissecting the interface between apicomplexan parasite and host cell: Insights from a divergent AMA-RON2 pair. PNAS, (2016) Jan 12;113(2):398-403. *equal contribution
Wang K, Peng ED, Huang AS, Xia D, Vermont SJ, Lentini G, Lebrun M, Wastling JM, Bradley PJ. Identification of Novel O-Linked Glycosylated Toxoplasma Proteins by Vicia villosa Lectin Chromatography. PLoS One, (2016) Mar 7;11(3):e0150561.
Delgadillo RF, Parker ML, Lebrun M, Boulanger MJ, Douguet D. Stability of the Plasmodium falciparum AMA1-RON2 Complex Is Governed by the Domain II (DII) Loop. PLoS One, (2016) Jan 5;11(1):e0144764.
Pihan E., Delgadillo RF., Tonkin ML., Pugnière M., Lebrun M., Boulanger MJ., Douguet D. Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex. J Comput Aided Mol Des, (2015) Jun;29(6):525-39
Rugarabamu G., Marq JB., Guérin A., Lebrun M., Soldati-Favre D. Distinct contribution of Toxoplasma gondii rhomboid proteases 4 and 5 to micronemal protein protease 1 activity during invasion. Mol Microbiol, (2015). Jul;97(2):244-62.
Lentini G., Kong-Hap M., El Hajj H., Francia M., Claudet C., Striepen B., Dubremetz JF., Lebrun M. Identification and characterization of Toxoplasma SIP, a conserved apicomplexan cytoskeleton protein involved in maintaining the shape, motility and virulence of the parasite. Cell Microbiol, (2015) 17(1):62-78.
Morlon-Guyot J., Pastore S., Berry L., Lebrun M., Daher W. Toxoplasma gondii Vps11, a subunit of HOPS and CORVET tethering complexes, is essential for the biogenesis of secretory organelles. Cell Microbiol, (2015) 1157-1178.
Daher W., Morlon-Guyot J., Sheiner L., Lentini G., Berry L., Tawk L., Dubremetz JF., Wengelnik K., Striepen B., Lebrun M. Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol, (2015) 559-578.
Risco-Castillo V., Topçu Selma., Marinach C., Manzon G., Bigorgne A.E., Briquet S., Baudin X., Lebrun M., Dubremetz J.F., and Olivier Silvie. Malaria Sporozoites Traverse Host Cells within Transient Vacuoles. Cell Host & Microbes, (2015) Nov 11;18(5):593-603.
Lamarque MH., Roques M., Kong-Hap M., Tonkin ML., Rugarabamu G., Marq JB., Penarete-Vargas DM., Boulanger MJ., Soldati-Favre D., Lebrun M. Plasticity and redundancy among AMA-RON pairs ensure host cell entry of Toxoplasma parasites. Nat Commun, (2014) Jun 17;5:4098.
Morlon-Guyot J., Berry L., Chen CT., Gubbels MJ., Lebrun M., Daher W. The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival. Cell Microbiol, (2014) 95-114.
Kong-Hap MA., Mouammine A., Daher W., Berry L., Lebrun M., Dubremetz JF., Besteiro S. Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii. Autophagy, (2013) September ;9(9):1334-48
Tonkin ML., Crawford J., Lebrun ML., Boulanger MJ. Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion. Protein Sci, (2011) Jan;22(1):114-27
De Napoli. M.G., N. de Miguel., Lebrun M., Moreno S.N.J., Angel S.O., Corvi M.M. N-terminal palmitoylation is required for Toxoplasma gondii HSP20 inner membrane complex localization. Biochimica and Biophysica Acta (BBA) - Molecular Cell Research, (2013) Jun;1833(6):1329-37.
Lebrun, M., Carruthers, V.B., Cesbron-Delauw, M.-F. Toxoplasma Secretory Proteins and their roles in Cell Invasion and Intracellular Survival. in Toxoplasma gondii: The Model Apicomplexan – Perspectives and Methods, Weiss and Kim (Eds), 2nd edition (2013) 265-315.
Dubremetz JF, Lebrun M. Virulence factors of Toxoplasma gondii. Microbes Infect, (2012) Dec;14(15):1403-10.
Lamarque MH, Papoin J, Finizio AL, Lentini G, Pfaff AW, Candolfi E, Dubremetz JF, Lebrun M. Identification of a new rhoptry neck complex RON9/RON10 in the Apicomplexa parasite Toxoplasma gondii. PLoS One, (2012);7(3):e32457.
Vulliez-Le Normand B, Tonkin ML, Lamarque MH, Langer S, Hoos S, Roques M, Saul FA, Faber BW, Bentley GA, Boulanger MJ, Lebrun M. Structural and functional insights into the malaria parasite moving junction complex. PLoS Pathog, (2012);8(6):e1002755.
Tawk, L., Dubremetz, J. F., Montcourrier, P., Chicanne, G., Merezegue, F., Richard, V., Payrastre, B., Meissner, M., Vial, H. J., Roy, C., Wengelnik, K., and Lebrun, M. Phosphatidylinositol 3-monophosphate is involved in Toxoplasma apicoplast biogenesis. PLoS Pathog, (2011) 7, e1001286
Besteiro S, Dubremetz JF, Lebrun M. The moving junction of apicomplexan parasites: a key structure for invasion. Cell Microbiol, (2011) Jun;13(6):797-805.
Lamarque M, Besteiro S, Papoin J, Roques M, Vulliez-Le Normand B, Morlon-Guyot J, Dubremetz JF, Fauquenoy S, Tomavo S, Faber BW, Kocken CH, Thomas AW, Boulanger MJ, Bentley GA, Lebrun M. The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites. PLoS Pathog, (2011) Feb 10;7(2):e1001276.
Hajagos BE, Turetzky JM, Peng ED, Cheng SJ, Ryan CM, Souda P, Whitelegge JP, Lebrun M, Dubremetz JF, Bradley PJ. Molecular dissection of novel trafficking and processing of the Toxoplasma gondii rhoptry metalloprotease toxolysin-1. Traffic, (2012) Feb;13(2):292-304.
Tonkin ML, Roques M, Lamarque MH, Pugnière M, Douguet D, Crawford J, Lebrun M*, Boulanger MJ*. Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide. Science, (2011) Jul 22;333(6041):463-7. *equal contribution
Mévélec MN, Ducournau C, Bassuny Ismael A, Olivier M, Sèche E, Lebrun M, Bout D, Dimier-Poisson I. Mic1-3 Knockout Toxoplasma gondii is a good candidate for a vaccine against T. gondii-induced abortion in sheep. Vet Res, (2010) Jul-Aug;41(4):49.
Moiré N, Dion S, Lebrun M, Dubremetz JF, Dimier-Poisson I. Mic1-3KO tachyzoite a live attenuated vaccine candidate against toxoplasmosis derived from a type I strain shows features of type II strain. Exp Parasitol, (2009) Oct;123(2):111-7.
AB Ismael, D Hedhli, O Cérède, M Lebrun, I Dimier-Poisson, and MN Mévélec. Further analysis of protection induced by the MIC3 DNA vaccine against T. gondii: CD4 and CD8 T Cells are the major effectors of the MIC3 DNA vaccine-induced protection, both Lectin-like and EGF-like domains of MIC3 conferred protection. Vaccine, (2009) 14;27(22):2959-66
S Besteiro, A Michelin, J Poncet, JF Dubremetz, M Lebrun. Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion. PloS Pathog, (2009) 5(2):e1000309. “Exceptional" by the Faculty of 1000”
Breinich, DJP. Ferguson2, BJ. Foth, GG. van Dooren, M Lebrun, DV. Quon, B Striepen, PJ. Bradley, F Frischknecht1, VB. Carruthers and Markus Meissner. An ancestral dynamin is required for the biogenesis of specialised secretory organelles in apicomplexan parasites. Current Biology, (2009) 19:277-86.
G Labesse, M Gelin, Y Bessin, M Lebrun, J Papoin, R Cerdan, S Arold, JF Dubremetz. ROP2 from Toxoplasma gondii: A virulence factor with a protein-kinase fold and no enzymatic activity. Structure, (2009) 17(1):139-46.
Sebastien Beistero Group:
Nguyen HM, Liu S, Daher W, Tan F, Besteiro S. (2018) Characterisation of two Toxoplasma PROPPINs homologous to Atg18/WIPI suggests they have evolved distinct specialised functions. PLoS One. Apr 16;13(4):e0195921.
Besteiro S. (2017) Autophagy in apicomplexan parasites. (2017) Curr Opin Microbiol. Dec;40:14-20.
Nguyen HM, Berry L, Sullivan WJ Jr, Besteiro S. (2017) Autophagy participates in the unfolded protein response in Toxoplasma gondii. FEMS Microbiol Lett. 15;364(15).
Di Cristina M, Dou Z, Lunghi M, Kannan G, Huynh MH, McGovern OL, Schultz TL, Schultz AJ, Miller AJ, Hayes BM, van der Linden W, Emiliani C, Bogyo M, Besteiro S, Coppens I, Carruthers VB. (2017) Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection. Nat Microbiol. Jun 19;2:17096.
Nguyen HM, El Hajj H, El Hajj R, Tawil N, Berry L, Lebrun M, Bordat Y, Besteiro S. (2017) Toxoplasma gondii autophagy-related protein ATG9 is crucial for the survival of parasites in their host. Cell Microbiol. 19(6).
Latré de Laté P, Pineda M, Harnett M, Harnett W, Besteiro S, Langsley G. (2017) Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells. Biomed J. 40(1):23-30.
Harnett MM, Pineda MA, Latré de Laté P, Eason RJ, Besteiro S, Harnett W, Langsley G. (2017). From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home. Biomed J. 40(1):9-22.
Lévêque MF, Nguyen HM, Besteiro S. (2016) Repurposing of conserved autophagy-related protein ATG8 in a divergent eukaryote. Commun Integr Biol. 9(4):e1197447.
Lévêque MF, Berry L, Cipriano MJ, Nguyen HM, Striepen B, Besteiro S. (2015) Autophagy-related protein ATG8 has a noncanonical function for Apicoplast inheritance in Toxoplasma gondii. MBio.;6(6):e01446-15.
Kong-Hap MA, Mouammine A, Daher W, Berry L, Lebrun M, Dubremetz JF, Besteiro S. (2013) Regulation of ATG8 membrane association by ATG4 in the parasitic protist Toxoplasma gondii. Autophagy. 9(9):1334-48
Besteiro S. (2012) Which roles for autophagy in Toxoplasma gondii and related apicomplexan parasites? Mol Biochem Parasitol. 184(1):1-8
Besteiro S. (2012) Role of Atg3 in the parasite Toxoplasma gondii : autophagy in an early branching eukaryote. Autophagy. 8 (3):435-7
Besteiro S, Brooks CF, Striepen B, Dubremetz JF. (2011) Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites. PLoS Pathog. 7(12):e100241