Laboratory of Pathogens and Host Immunity

Publications

SELECTED publications

Leon-Icaza SA, Frétaud M, Cornélie S, Bureau C, Yatime L, Floto RA, Renshaw SA, Herrmann JL, Langevin C, Cougoule C, Bernut A (2025) Curcumin-mediated NRF2 induction limits inflammatory damage in preclinical models of cystic fibrosis. Biomed Pharmacother 186:117957. doi:10.1016/j.biopha.2025.117957

Besse A, Menetrey Q, Jean-Pierre V, Huc-Brandt S, Aujoulat F, Dupont C, Chiron R, Armengaud J, Jumas-Bilak E, Molle V, Grenga L, Marchandin H (2025) Achromobacter xylosoxidans modulates Pseudomonas aeruginosa virulence through a complex multi-target competition. Sci Rep 15:23392. doi:10.1038/s41598-025-06075-w

Weimann A, Dinan AM, Ruis C, Bernut A, Pont S, Brown K, Ryan J, Santos L, Ellison L, Ukor E, Pandurangan AP, Krokowski S, Blundell TL, Welch M, Blane B, Judge K, Bousfield R, Brown N, Bryant JM, Kukavica-Ibrulj I, Rampioni G, Leoni L, Harrison PT, Peacock SJ, Thomson NR, Gauthier J, Fothergill JL, Levesque RC, Parkhill J, Floto RA (2024) Evolution and host-specific adaptation of Pseudomonas aeruginosa. Science 385(6704):eadi0908. doi:10.1126/science.adi0908

Le Moigne V, Rodriguez Rincon D, Glatigny S, Dupont CM, Langevin C, Ait Ali Said A, Renshaw SA, Floto RA, Herrmann JL, Bernut A (2022) Roscovitine worsens Mycobacterium abscessus infection by reducing DUOX2-mediated neutrophil response. Am J Respir Cell Mol Biol 66, 439-451. doi:10.1165/rcmb.2021-0406OC

Bernut A, Loynes CA, R Floto A, Renshaw SA (2020) Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation. Front Immunol 11, 1733. doi:10.3389/fimmu.2020.01733

Batalha IL, Bernut A, Schiebler M, Ouberai MM, Passemar C, Klapholz C, Kinna S, Michel S, Sader K, Castro-Hartmann P, Renshaw SA, Welland ME, Floto RA (2019). Polymeric nanobiotics as a novel treatment for mycobacterial infections. J Control Release 314, 116-124. doi:10.1016/j.jconrel.2019.10.009

Bernut A, Dupont C, Ogryzko NV, Neyret A, Herrmann JL, Floto RA, Renshaw SA, Kremer L (2019). CFTR protects against Mycobacterium abscessus infection by fine-tuning host oxidative defences. Cell Rep 26:1828-40.e4. doi:10.1016/j.celrep.2019.01.071

Le Moigne V, Bernut A, Cortes M, Viljoen AJ, Dupont C, Pawlik A, Gaillard JL, Misguich F, Crémazy F, Kremer L, Herrmann JL (2019). Lsr2 is a crucial determinant of intracellular growth and virulence in Mycobacterium abscessus. Front Microbiol 10:905. doi:10.3389/fmicb.2019.00905

Dubois V, Viljoen A, Laencina L, Moigne V, Bernut A, Dubar F, Blaise M, Gaillard JL, Guérardel Y, Kremer L, Herrmann JL, Misguich F (2018). MmpL8MAB controls Mycobacterium abscessus virulence and production of a previously unknown glycolipid family. Proc Natl Acad Sci USA 115:E10147-E56. doi:10.1073/pnas.1812984115

Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL, Misguich F (2018). Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus. Proc Natl Acad Sci USA 115:E1002-E10. doi:10.1073/pnas.1713195115

Lefebvre AL, Lemoigne V, Bernut A, Veckerlé C, Compain F, Herrmann JL, Kremer L, Arthur M, Mainardi JL (2017). Inhibition of the β-lactamase BlaMab by avibactam improves the in vitro and in vivo efficacy of imipenem against Mycobacterium abscessus. Antimicrob Agents Chemother 61:e02440-16. doi:10.1128/AAC.02440-16

Bernut A, Viljoen A, Dupont C, Sapriel G, Blaise M, Bouchier C, Brosch R, de Chastellier C, Herrmann JL, Kremer L (2016). Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members. Mol Microbiol 99:866-83. doi:10.1111/mmi.13283

Bernut A, Nguyen-Chi M, Halloum I, Herrmann JL, Lutfalla G, Kremer L (2016) Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking. PLoS Pathog 12: e1005986. doi:10.1371/journal.ppat.100598

Halloum I, Carrère-Kremer S, Blaise M, Viljoen A, Bernut A, Le Moigne V, Vilchèze C, Guérardel Y, Lutfalla G, Herrmann JL, Jacobs WR jr, Kremer L (2016). Deletion of a new dehydratase obliterates cording and virulence of rough Mycobacterium abscessus. Proc Natl Acad Sci USA 113:E4228-37. doi:10.1073/pnas.1605477113

Bernut A, Herrmann JL, Kissa K, Dubremetz JF, Gaillard JL, Lutfalla G, Kremer L (2014) Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation. Proc Natl Acad Sci USA 111:E943-52. doi:10.1073/pnas.1321390111

Brugirard-Ricaud K, Duchaud E, Givaudan A, Girard PA, Kunst F, Boemare N, Brehélin M, Zumbihl R (2005) Site-specific antiphagocytic function of the Photorhabdus luminescens type III secretion system during insect colonization. Cell Microbiol 7:363-71. doi:10.1111/j.1462-5822.2004.00466.x