Publications – Group A. Bernut

Recent publications

Le Moigne V, Rodriguez Rincon D, Glatigny S, Dupont CM, Langevin C, Ait Ali Said A, Renshaw SA, Floto RA, Herrmann JL, Bernut A (2022) Roscovitine worsens Mycobacterium abscessus infection by reducing DUOX2-mediated neutrophil response. Am J Respir Cell Mol Biol 66, 439-451. doi:10.1165/rcmb.2021-0406OC

Bernut A, Loynes CA, R Floto A, Renshaw SA (2020) Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation. Front Immunol 11, 1733. doi:10.3389/fimmu.2020.01733

Batalha IL, Bernut A, Schiebler M, Ouberai MM, Passemar C, Klapholz C, Kinna S, Michel S, Sader K, Castro-Hartmann P, Renshaw SA, Welland ME, Floto RA (2019). Polymeric nanobiotics as a novel treatment for mycobacterial infections. J Control Release 314, 116-124. doi:10.1016/j.jconrel.2019.10.009

Bernut A, Dupont C, Ogryzko NV, Neyret A, Herrmann JL, Floto RA, Renshaw SA, Kremer L (2019). CFTR protects against Mycobacterium abscessus infection by fine-tuning host oxidative defences. Cell Rep 26:1828-40.e4. doi:10.1016/j.celrep.2019.01.071

Le Moigne V, Bernut A, Cortes M, Viljoen AJ, Dupont C, Pawlik A, Gaillard JL, Misguich F, Crémazy F, Kremer L, Herrmann JL (2019). Lsr2 is a crucial determinant of intracellular growth and virulence in Mycobacterium abscessus. Front Microbiol 10:905. doi:10.3389/fmicb.2019.00905

Dubois V, Viljoen A, Laencina L, Moigne V, Bernut A, Dubar F, Blaise M, Gaillard JL, Guérardel Y, Kremer L, Herrmann JL and Misguich F (2018). MmpL8MAB controls Mycobacterium abscessus virulence and production of a previously unknown glycolipid family. Proc Natl Acad Sci USA 115:E10147-E56. doi:10.1073/pnas.1812984115

Malcolm KC, Caceres SM, Pohl K, Poch KR, Bernut A, Kremer L, Bratton DL, Herrmann JL and Nick JA (2018). Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms. PLoS One 13:e0196120. doi:10.1371/journal.pone.0196120

Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL and Misguich F (2018). Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus. Proc Natl Acad Sci USA 115:E1002-E10. doi:10.1073/pnas.1713195115

Lefebvre AL, Lemoigne V, Bernut A, Veckerlé C, Compain F, Herrmann JL, Kremer L, Arthur M and Mainardi JL (2017). Inhibition of the β-lactamase BlaMab by avibactam improves the in vitro and in vivo efficacy of imipenem against Mycobacterium abscessus. Antimicrob Agents Chemother 61:e02440-16. doi:10.1128/AAC.02440-16

Bernut A, Viljoen A, Dupont C, Sapriel G, Blaise M, Bouchier C, Brosch R, de Chastellier C, Herrmann JL and Kremer L (2016). Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members. Mol Microbiol 99:866-83. doi:10.1111/mmi.13283

Bernut A, Nguyen-Chi M, Halloum I, Herrmann JL, Lutfalla G, Kremer L (2016) Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking. PLoS Pathog 12: e1005986. doi:10.1371/journal.ppat.100598

Singh V, Berry L, Bernut A, Singh S, Carrère-Kremer S, Viljoen A, Alibaud L, Chaturvedi V, Geurtsen J, Drancourt M and Kremer L (2016). A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts. Cell Microbiol 18:1489-507. doi:10.1111/cmi.12606

Le Moigne V, Belon C, Goulard C, Accard G, Bernut A, Pitard B, Gaillard JL, Kremer L, Herrmann JL and Blanc-Potard AB (2016). MgtC as a host-induced factor and vaccine candidate against Mycobacterium abscessus infection. Infec Immun 84:2895-903. doi:10.1128/IAI.00359-16

Halloum I, Carrère-Kremer S, Blaise M, Viljoen A, Bernut A, Le Moigne V, Vilchèze C, Guérardel Y, Lutfalla G, Herrmann JL, Jacobs WR jr and Kremer L (2016). Deletion of a new dehydratase obliterates cording and virulence of rough Mycobacterium abscessus. Proc Natl Acad Sci USA 113:E4228-37. doi:10.1073/pnas.1605477113