Publications – Team 7
2025
Leon-Icaza SA, Frétaud M, Cornélie S, Bureau C, Yatime L, Floto RA, Renshaw SA, Herrmann JL, Langevin C, Cougoule C, Bernut A (2025) Curcumin-mediated NRF2 induction limits inflammatory damage in preclinical models of cystic fibrosis. Biomed Pharmacother 186:117957. doi:10.1016/j.biopha.2025.117957
Pont S, Nilly F, Berry L, Bonhoure A, Alford MA, Louis M, Nogaret P, Bains M, Lesouhaitier O, Hancock REW, Plésiat P, Blanc-Potard AB (2025) Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model. PLoS Pathog 21:e1012922. doi:10.1371/journal.ppat.1012922
Muir CF, Reyes-Aldasoro CC, Prajsnar TK, Michno BJ, Cholewa-Waclaw J, Ho YX, Bernut A, Loynes CA, Elworthy S, Bowden KA, Cadby AJ, Prince LR, King JS, Ellett F, Condliffe AM, Renshaw SA (2025) A subset of neutrophil phagosomes is characterised by pulses of Class I PI3K activity. Dis Model Mech doi:10.1242/dmm.052042
Besse A, Menetrey Q, Jean-Pierre V, Huc-Brandt S, Aujoulat F, Dupont C, Chiron R, Armengaud J, Jumas-Bilak E, Molle V, Grenga L, Marchandin H (2025) Achromobacter xylosoxidans modulates Pseudomonas aeruginosa virulence through a complex multi-target competition. Sci Rep 15:23392. doi:10.1038/s41598-025-06075-w
Costes F, Nilly F, Rousset A, Pont S, Moreau K, Blanc-Potard AB (2025) Modeling Pseudomonas aeruginosa–Staphylococcus aureus interactions in zebrafish to assess the host inflammatory response upon co-infection. Sci Rep 15:23965. doi:10.1038/s41598-025-08459-4
Nilly F, Blanc-Potard A (2025) Modeling Persistent Pseudomonas aeruginosa Infection in Wounded Zebrafish Larvae. J Vis Exp e68464. doi:10.3791/68464
2024
Weimann A, Dinan AM, Ruis C, Bernut A, Pont S, Brown K, Ryan J, Santos L, Ellison L, Ukor E, Pandurangan AP, Krokowski S, Blundell TL, Welch M, Blane B, Judge K, Bousfield R, Brown N, Bryant JM, Kukavica-Ibrulj I, Rampioni G, Leoni L, Harrison PT, Peacock SJ, Thomson NR, Gauthier J, Fothergill JL, Levesque RC, Parkhill J, Floto RA (2024) Evolution and host-specific adaptation of Pseudomonas aeruginosa. Science 385(6704):eadi0908. doi:10.1126/science.adi0908
Aissaoui N, Mills A, Lai-Kee-Him J, Triomphe N, Cece Q, Doucet C, Bonhoure A, Vidal M, Ke Y, Bellot G. Free-Standing DNA Origami Superlattice to Facilitate Cryo-EM Visualization of Membrane Vesicles (2024) J Am Chem Soc 146:12925-12932. doi:10.1021/jacs.3c07328
Leiba J, Sipka T, Begon-Pescia C, Bernardello M, Tairi S, Bossi L, Gonzalez AA, Mialhe X, Gualda E, Loza-Alvarez P, Blanc-Potard A, Lutfalla G, Nguyen-Chi M (2024) Dynamics of macrophage polarization support Salmonella persistence in a whole living organism. Elife 13:e89828. doi:10.7554/eLife.89828
Hajjar H, Berry L, Wu Y, Touqui L, Vergunst AC, Blanc-Potard AB (2024) Contribution of intramacrophage stages to Pseudomonas aeruginosa infection outcome in zebrafish embryos: insights from mgtC and oprF mutants. Sci Rep 14(1):6297. doi:10.1038/s41598-024-56725-8
2023
Rahimova R, Nogaret P, Huteau V, Gelin M, Clément DA, Labesse G, Pochet S, Blanc-Potard AB, Lionne C (2023) Structure-based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase. FEBS J 290:482-501. doi:10.1111/febs.16604
2022
Le Moigne V, Rodriguez Rincon D, Glatigny S, Dupont CM, Langevin C, Ait Ali Said A, Renshaw SA, Floto RA, Herrmann JL, Bernut A (2022) Roscovitine worsens Mycobacterium abscessus infection by reducing DUOX2-mediated neutrophil response. Am J Respir Cell Mol Biol 66:439-451. doi:10.1165/rcmb.2021-0406OC
Bonhoure A, Henry L, Bich C, Blanc L, Bergeret B, Bousquet MP, Coux O, Stoebner PE, Vidal M (2022) Extracellular 20S proteasome secreted via microvesicles can degrade poorly folded proteins and inhibit Galectin-3 agglutination activity. Traffic 23:287-304. doi:10.1111/tra.12840
Magnan C, Ahmad-Mansour N, Pouget C, Morsli M, Huc-Brandt S, Pantel A, Dunyach-Remy C, Sotto A, Molle V, Lavigne JP (2022) Phenotypic and Genotypic Virulence Characterisation of Staphylococcus pettenkoferi Strains Isolated from Human Bloodstream and Diabetic Foot Infections. International Journal of Molecular Sciences 23:15476. doi:10.3390/ijms232415476
Ahmad-Mansour N, Elhawy MI, Huc-Brandt S, Youssouf N, Pätzold L, Martin M, Abdel-Wadood N, Aljohmani A, Morsli M, Krasteva-Christ G, Becker SL, Yildiz D, Lavigne JP, Gannoun-Zaki L, Bischoff M, Molle V (2022) Characterization of the Secreted Acid Phosphatase SapS Reveals a Novel Virulence Factor of Staphylococcus aureus That Contributes to Survival and Virulence in Mice. International Journal of Molecular Sciences 23:14031. doi:10.3390/ijms232214031
Benthien H, Fresenborg B, Pätzold L, Elhawy M I, Huc-Brandt S, Beisswenger C, Krasteva-Christ G, Becker S L, Molle V, Knobloch J K, Bischoff M (2022) The Transcription Factor SpoVG Is of Major Importance for Biofilm Formation of Staphylococcus epidermidis under In Vitro Conditions, but Dispensable for In Vivo Biofilm Formation. International Journal of Molecular Sciences 23:3255. doi:10.3390/ijms23063255
2021
Blanc-Potard AB, Groisman EA (2021) How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues. Trends Microbiol 29:98-106. doi:10.1016/j.tim.2020.07.003
Elhawy MI, Huc-Brandt S, Patzold L, Gannoun-Zaki L, Abdrabou AM, Bischoff M, and Molle V (2021) The Phosphoarginine Phosphatase PtpB from Staphylococcus aureus Is Involved in Bacterial Stress Adaptation during Infection. Cells 10:645. doi:10.3390/cells10030645
Pont S, Blanc-Potard AB (2021) Zebrafish Embryo Infection Model to Investigate Pseudomonas aeruginosa Interaction With Innate Immunity and Validate New Therapeutics. Front Cell Infect Microbiol 11:745851. doi:10.3389/fcimb.2021.745851
Ahmad-Mansour N, Plumet L, Huc-Brandt S, Magnan C, Yahiaoui-Martinez A, Kissa K, Pantel A, Lavigne JP, Molle V (2021) Investigating Pathogenicity and Virulence of Staphylococcus pettenkoferi: An Emerging Pathogen. International Journal of Molecular Sciences 22:13614. doi:10.3390/ijms222413614
Sacher-Pirklbauer A, Klein-Jöbstl D, Sofka D, Blanc-Potard AB, Hilbert F (2021) Phylogenetic Groups and Antimicrobial Resistance Genes in Escherichia coli from Different Meat Species. Antibiotics 10:1543. doi:10.3390/antibiotics10121543
Nogaret P, El Garah F, Blanc-Potard AB (2021) A Novel Infection Protocol in Zebrafish Embryo to Assess Pseudomonas aeruginosa Virulence and Validate Efficacy of a Quorum Sensing Inhibitor In Vivo. Pathogens 10:401. doi:10.3390/pathogens10040401
Moussouni M, Berry L, Sipka T, Nguyen-Chi M, Blanc-Potard AB (2021) Pseudomonas aeruginosa OprF plays a role in resistance to macrophage clearance during acute infection. Sci Rep 11, 359. doi:10.1038/s41598-020-79678-0
Bonhoure A, Henry L, Morille M, Aissaoui N, Bellot G, Stoebner PE, Vidal M (2021) Melanotransferrin is efficiently sorted on the surface of exosomes secreted by melanoma cells. Melanoma Res 31:338-351. doi:10.1097/CMR.0000000000000741
2020
Bernut A, Loynes CA, R Floto A, Renshaw SA (2020) Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation. Front Immunol 11,1733. doi:10.3389/fimmu.2020.01733
Martinez E, Huc-Brandt S, Brelle S, Allombert J, Cantet F, Gannoun-Zaki L, Burette M, Martin M, Letourneur F, Bonazzi M, Molle V (2020) The secreted protein kinase CstK from Coxiella burnetii influences vacuole development and interacts with the GTPase-activating host protein TBC1D5. Journal of Biological Chemistry 2957391-7403. doi:10.1074/jbc.RA119.010112
Le Moigne V, Raynaud C, Moreau F, Dupont C, Nigou J, Neyrolles O, Kremer L, Herrmann JL (2020) Efficacy of Bedaquiline, Alone or in Combination with Imipenem, against Mycobacterium abscessus in C3HeB/FeJ Mice. Antimicrob Agents Chemother 64:e00114-20. doi:10.1128/AAC.00114-20
Garai P and Blanc-Potard AB (2020) Uncovering small membrane proteins in pathogenic bacteria: regulatory functions and therapeutic potential. Mol Microbiol 114:710-720. doi:10.1111/mmi.14564
de Ruyck J, Dupont C, Lamy E, Le Moigne V, Biot C, Guérardel Y, Herrmann JL, Blaise M, Grassin-Delyle S, Kremer L, Dubar F (2020) Structure-Based Design and Synthesis of Piperidinol-Containing Molecules as New Mycobacterium abscessus Inhibitors. ChemistryOpen (3):351-365. doi:10.1002/open.202000042
2019
Batalha IL, Bernut A, Schiebler M, Ouberai MM, Passemar C, Klapholz C, Kinna S, Michel S, Sader K, Castro-Hartmann P, Renshaw SA, Welland ME and Floto RA (2019) Polymeric nanobiotics as a novel treatment for mycobacterial infections. J Control Release 314:116-24. doi:10.1016/j.jconrel.2019.10.009
Bernut A, Dupont C, Ogryzko NV, Neyret A, Herrmann JL, Floto RA, Renshaw SA, Kremer L (2019) CFTR protects against Mycobacterium abscessus infection by fine-tuning host oxidative defences. Cell Rep 26:1828-40.e4. doi:10.1016/j.celrep.2019.01.071
Bec N, Bonhoure A, Henry L, Berry L, Larroque C, Coux O, Stoebner PE, Vidal M (2019) Proteasome 19S RP and translation preinitiation complexes are secreted within exosomes upon serum starvation. Traffic 20:516-536. doi:10.1111/tra.12653
Garai P, Berry L, Moussouni M, Bleves S, Blanc-Potard AB (2019) Killing from the inside: Intracellular role of T3SS in the fate of Pseudomonas aeruginosa within macrophages revealed by mgtC and oprF mutants. PLOS Pathogens 15:e1007812. doi:10.1371/journal.ppat.1007812
Dupont C, Chen Y, Xu Z, Roquet-Banères F, Blaise M, Witt AK, Dubar F, Biot C, Guérardel Y, Maurer FP, Chng SS, Kremer L (2019) A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3. J Biol Chem 294:17512-17523. doi:10.1074/jbc.RA119.010135
Moussouni M, Nogaret P, Garai P, Ize B, Vives E, Blanc-Potard AB (2019) Activity of a synthetic peptide targeting MgtC on Pseudomonas aeruginosa intramacrophage survival and biofilm formation. Front Cell Infect Microbiol 9:84. doi:10.3389/fcimb.2019.00084
Le Moigne V, Bernut A, Cortès M, Viljoen A, Dupont C, Pawlik A, Gaillard JL, Misguich F, Crémazy F, Kremer L, Herrmann JL (2019) Lsr2 Is an Important Determinant of Intracellular Growth and Virulence in Mycobacterium abscessus. Front Microbiol 30;10:905. doi:10.3389/fmicb.2019.00905
Olvera MR, Garai P, Mongin G, Vivès E, Gannoun-Zaki L, Blanc-Potard AB (2019) Synthetic hydrophobic peptides derived from MgtR weaken Salmonella pathogenicity and work with a different mode of action than endogenously produced peptides. Sci Rep 9:15253. doi:10.1038/s41598-019-51760-2