Laboratory of Pathogens and Host Immunity

Publications – Team T. Hollin

RECENT PUBLICATIONS

Chahine ZM, Gupta M, Lenz T, Hollin T, Abel S, Banks C, Saraf A, Prudhomme J, Bhanvadia S, Florens LA, Le Roch KG (2024) PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum. Elife 12:RP92499. doi:10.7554/eLife.92499

Hollin T, Abel S, Banks C, Hristov B, Prudhomme J, Hales K, Florens L, Stafford Noble W, Le Roch KG (2024) Proteome-Wide Identification of RNA-dependent proteins and an emerging role for RNAs in Plasmodium falciparum protein complexes. Nat Commun 15(1):1365. doi:10.1038/s41467-024-45519-1

Hollin T, Le Roch KG (2023) Sex determination and transmission: Leveraging genetic screens to reveal Plasmodium’s secrets. Cell Host Microbe 31(9):1430-1432. doi:10.1016/j.chom.2023.08.007

Mansour H, Cabezas-Cruz A, Peucelle V, Farce A, Salomé-Desnoulez S, Metatla I, Guerrera IC, Hollin T, Khalife J (2023) Characterization of GEXP15 as a Potential Regulator of Protein Phosphatase 1 in Plasmodium falciparum. Int J Mol Sci 24(16):12647. doi:10.3390/ijms241612647

Batugedara G, Lu XM, Hristov B, Abel S, Chahine Z, Hollin T, Williams D, Wang T, Cort A, Lenz T, Thompson TA, Prudhomme J, Tripathi AK, Xu G, Cudini J, Dogga S, Lawniczak M, Noble WS, Sinnis P, Le Roch KG (2023) Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum. Nat Commun 14(1):5086. doi:10.1038/s41467-023-40883-w

Hollin T, Chahine Z, Le Roch KG (2023) Epigenetic Regulation and Chromatin Remodeling in Malaria Parasites. Annu Rev Microbiol 77:255-276. doi:10.1146/annurev-micro-032521-041554

Hollin T, Abel S, Falla A, Pasaje CFA, Bhatia A, Hur M, Kirkwood JS, Saraf A, Prudhomme J, De Souza A, Florens L, Niles JC, Le Roch KG (2022) Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum. Nat Commun 13(1):1275. doi:10.1038/s41467-022-28981-7

Hollin T, Abel S, Le Roch KG (2021) Genome-Wide Analysis of RNA-Protein Interactions in Plasmodium falciparum Using eCLIP-Seq. Methods Mol Biol 2369:139-164. doi:10.1007/978-1-0716-1681-9_9

Hollin T, Jaroszewski L, Stajich JE, Godzik A, Le Roch KG (2021) Identification and phylogenetic analysis of RNA binding domain abundant in apicomplexans or RAP proteins. Microb Genom 7(3):mgen000541. doi:10.1099/mgen.0.000541

Davis SZ, Hollin T, Lenz T, Le Roch KG (2021) Three-dimensional chromatin in infectious disease-A role for gene regulation and pathogenicity? PLoS Pathog 17(2):e1009207. doi:10.1371/journal.ppat.1009207

Hollin T, Le Roch KG (2020) From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium. Front Cell Infect Microbiol 10:618454. doi:10.3389/fcimb.2020.618454

Hollin T, Gupta M, Lenz T, Le Roch KG (2021) Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites. Trends Genet 37(1):73-85. doi:10.1016/j.tig.2020.09.003

Pandey R, Abel S, Boucher M, Wall RJ, Zeeshan M, Rea E, Freville A, Lu XM, Brady D, Daniel E, Stanway RR, Wheatley S, Batugedara G, Hollin T, Bottrill AR, Gupta D, Holder AA, Le Roch KG, Tewari R (2020) Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission. Cell Rep 30(6):1883-1897.e6. doi:10.1016/j.celrep.2020.01.033

Hollin T, De Witte C, Fréville A, Guerrera IC, Chhuon C, Saliou JM, Herbert F, Pierrot C, Khalife J (2019) Essential role of GEXP15, a specific Protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission. PLoS Pathog 15(7):e1007973. doi:10.1371/journal.ppat.1007973

Lenne A, De Witte C, Tellier G, Hollin T, Aliouat EM, Martoriati A, Cailliau K, Saliou JM, Khalife J, Pierrot C (2018) Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Protein in Plasmodium falciparum. Front Microbiol 9:2617. doi:10.3389/fmicb.2018.02617

Hollin T, De Witte C, Lenne A, Pierrot C, Khalife J (2016) Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 in Plasmodium falciparum. BMC Genomics 17:246. doi:10.1186/s12864-016-2571-z