News – Group L. Yatime
OCTOBER 2023
New publication in FEBS Journal about the IbeA virulence factor from AIEC by Paris et al
Our group has elucidated the role of the IbeA protein, a virulence factor from the adherent invasive Escherichia coli (AIEC) strain involved in the pathogenesis of Crohn’s disease.
The biological function of this protein has long remained of debate. But this new study,conducted by PhD student Théo Paris, has allowed to demonstrate that IbeA function as a FAD-dependent oxidoreductase, thus permitting survival of the AIEC bacteria within the highly oxidative environment of the phagosomal compartments within host macrophages through the modulation of redox processes.