Host- and Pathogen-mediated Inflammation in Crohn’s disease

Head of group: Dr. Laure Yatime

We are interested in the molecular actors of the innate immune system whose excessive activation by pathogenic or endogenous danger signals causes chronic inflammation related to human pathologies such as hemolytic diseases, inflammatory bowel diseases or cancers. Our current work aims to understand how the recognition of these danger signals by specific immune receptors generates a pro-inflammatory response promoting the progression of these pathologies.

To this purpose, we use a multidisciplinary approach combining biochemistry, cell biology, structural biology and in vivo modeling in zebrafish.

News

April 2026 – New publication in the team on RAGE:S100 interactions

December 2025 – First characterization of zebrafish-specific S100 proteins published in FEBS Journal

November 2024 – Liz defends her PhD thesis. Congratulations Dr. Hernandez Perez!