Hereditary Hemorrhagic Telangiectasia & Inflammation

Head of group: Dr. Etienne Lelièvre

We are studying the Endoglin-dependent mechanisms underlying hereditary hemorrhagic telangiectasia (HHT or Rendu-Osler Weber disease), a rare genetic disorder linked to dysfunctions in the TGFbeta pathways and characterized by abnormal blood vessel formation, using a zebrafish mutant model that recapitulates key symptoms of the human pathology.

News

Check out our latest paper in Disease Models & Mechanisms in which we describe the role of endoglin in heart failure and present a new in vivo model of hereditary hemorrhagic telangiectasia in zebrafish!