News – Team 6

PhD defense of Resul Ozbilgic

On November 25th, Resul Ozbilgic defended his PhD thesis entitled “Molecular basis of macrophage polarization during inflammatory episodes” and supervised by Dr. Mai Nguyen-Chi.

The jury was composed of Dr. Nadia Soussi-Yanicostas (Neuro-Diderot, Paris), Dr. Renaud Poincloux (IPBS, Toulouse) and Dr. Bénédicte Chazaud (INMG, Lyon).

PhD defense of Liz Hernandez Perez

On November 22nd, Liz Hernandez Perez defended her PhD thesis entitled “High content pharmacological screening in zebrafish – Targeting S100 alarmins for anti-inflammatory applications” and supervised by Drs. Laure Yatime and Mai Nguyen-Chi.

The jury was composed of Dr. Christelle Langevin (INRAE, Jouy-en-Josas), Dr. Alexandre Boissonnas (CIMI, Paris) and Dr. Lubka Roumenina (CRC, Paris).

PhD defense of Maria Demou

On October 8th, Maria Demou defended her PhD thesis entitled “Functional and Structural Characterization of extracellular S100 proteins, mediators of inflammation in human diseases” and supervised by Dr. Laure Yatime.

The jury was composed of Dr. Isabelle Landrieu (Pasteur Institute, Lille), Dr. Christine Gaboriaud (IBS, Grenoble) and Dr. William Bourguet (CBS, Montpellier).

‘Article of the Month’ prize from SFBBM awarded to Theo Paris

Theo received this prize from SFBBM for his article on the IbeA virulence factor from adherent invasive E. coli.

Congratulations!

Link to the SFBBM website

INFLANET meeting in Visegard, Hungary

The final INFLANET review meeting was held on March 23-24 in the beautiful city of Visegrad in Hungary.

The meeting was combined to the European Phagocyte Workshop and the satellite INFLANET Dissemination conference.

All our ESRs gave great talks at the meetings on their latest scientific results.

All the participants also enjoyed a well-deserved break with a medieval dinner at the Renaissance restaurant!

‘Colloque Français des Jeunes Chercheurs VLM’ in Paris

Flore wins the ‘Best Talk’ award at the CFJC VLM 2024 in Paris. Congratulations!

Sarahdja and Floriane had also great talk and poster sessions.

Well done, girls!

New publication in eLife journal by the group of M. Nguyen Chi

Illuminating the hiding place of Salmonella in living host – The group of Mai Nguyen Chi developed a new model of persistent infection in zebrafish allowing to visualize in live where Salmonella enterica establishes its niche to persist long-term in the host. This study showed that Salmonella persist in anti-inflammatory/ pro-regenerative motionless macrophages.

Link to the article

PhD defense of Théo Paris

On November 27th, Théo Paris defended his PhD thesis entitled “Virulence mechanisms of adherent invasive Escherichia coli and antibacterial strategies in Crohn’s disease” and supervised by Dr. Laure Yatime.

The jury was composed of Dr. Laurent Terradot (MMSB, Lyon), Dr. Pierre Germon (INRAE, Tours), Dr. Elisabeth Billard (M2iSH, Clermont-Ferrand) and Dr. Pierre Boudinot (INRAE, Jouy-en-Josas).

Novel lymphoid organ in the zebrafish, and other teleost fish

A collaborative study between groups from University of Oslo, INRAE, A*STAR, Wageningen University & Research, CNRS and the group of Mai Nguyen Chi identifies a new tonsil-like organ in fish which probably protect them from pathogens and suggests that the fish immune system is more sophisticated than previously thought.

The study was just published in Science Advances and made the cover of the November issue. It was also highlighted in a Commentary in Science.

Link to the article

Link to the commentary in Science

New publication in FEBS Journal about the IbeA virulence factor from AIEC by Paris et al

The group of Laure Yatime has elucidated the role of the IbeA protein, a virulence factor from the adherent invasive Escherichia coli (AIEC) strain involved in the pathogenesis of Crohn’s disease.

The biological function of this protein has long remained of debate. But this new study,conducted by PhD student Théo Paris, has allowed to demonstrate that IbeA function as a FAD-dependent oxidoreductase, thus permitting survival of the AIEC bacteria within the highly oxidative environment of the phagosomal compartments within host macrophages through the modulation of redox processes.

Link to the article

Welcome to Floriane Costes who starts her PhD thesis in the lab!

Congratulations to Anne Blanc-Potard who obtains an ANR PRC grant at the AAPG 2023!