Publications – Team 2
2024
Castellano CM, Lacroix L, Mathis E, Prorok P, Hennion M, Lopez-Rubio JJ, Mechali, M, Gomes AR. (2024) The genetic landscape of origins of replication in P. falciparum. Nucleic Acids Res. 52(2):660-676 10.1093/nar/gkad1103
2023
Mohamed BS, Nguyen MC, Wein S, Uttaro JP, Robert X, Violot S, Ballut L, Jugnarain V, Mathé C, Cerdan R, Aghajari N, Peyrottes S (2023) Purine containing carbonucleoside phosphonate analogues as novel chemotype for Plasmodium falciparum Inhibition. Eur J Med Chem 258:115581. doi:10.1016/j.ejmech.2023.115581
Lohia R, Allegrini B, Berry L, Guizouarn H, Cerdan R, Abkarian M, Douguet D, Honoré E, Wengelnik K (2023) Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion. Cell Mol Life Sci 80:124. doi:10.1007/s00018-023-04773-0
Ukegbu CV, Gomes AR, Giorgalli M, Campos M, Bailey AJ, Besson TRB, Billker O, Vlachou D, Christophides GK (2023) Identification of genes required for Plasmodium gametocyte-to-sporozoite development in the mosquito vector. Cell Host Microbe 31:1539-1551.e6. doi:10.1016/j.chom.2023.08.010
2022
Gomes AR, Marin-Menendez A, Adjalley S, Bardy C, Cassan C, Lee M, et al (2022) A transcriptional switch controls sex determination in Plasmodium falciparum. Nature 612:528-533. doi:10.1038/s41586-022-05509-z
Ward D, Gomes AR, Tetteh K, Sepulveda N, Gomez LF, Campino S, Clark TG (2022) Sero-epidemiological study of arbovirus infection following the 2015–2016 Zika virus outbreak in Cabo Verde. Sci Rep 12:11719. doi:10.1038/s41598-022-16115-4
2021
Gurung P, Gomes AR, Martins RM, Juranek SA, Alberti P, Mbang‐Benet D, et al (2021) PfGBP2 is a novel G‐quadruplex binding protein in Plasmodium falciparum. Cell Microbiol 23:e13303. doi:10.1111/cmi.13303
2020
Campos M, Ward D, Morales RF, Gomes AR, Silva K, Sepúlveda N, et al (2020) Surveillance of Aedes aegypti populations in the city of Praia, Cape Verde: Zika virus infection, insecticide resistance and genetic diversity. Parasit Vectors 13:481. doi:10.1186/s13071-020-04356-z
Gazanion E, Lacroix L, Alberti P, Gurung P, Wein S, Mergny JL, Gomes AR* and Lopez-Rubio JJ* (2020) Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites. PLoS Genet 16:e1008917. doi:10.1371/journal.pgen.1008917. *Co-senior authorship
Cheviet T, Wein S, Bourchenin G, Lagacherie M, Périgaud C, Cerdan R*, Peyrottes S* (2020) β-Hydroxy- A nd β-Aminophosphonate Acyclonucleosides as Potent Inhibitors of Plasmodium falciparum Growth. J Med Chem 63:8069-8087. doi:10.1021/acs.jmedchem.0c00131.*Co-senior authorship
2019
Berger O, Ortial S, Wein S, Denoyelle S, Bressolle F, Durand T, Escale R, Vial HJ, Vo-Hoang Y (2019) Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials. Bioorg Med Chem Lett 29:2203-2207. doi:10.1016/j.bmcl.2019.06.045
Benavente ED, Gomes AR, Silva JR, Grigg MJ, Walker H, Barber B, William T, Yeo TW, Sessions PF, Ramaprasad A, Ibrahim A, Charleston J, …, Campino SG, Clark T (2019) Whole genome sequencing of amplified Plasmodium knowlesi DNA from unprocessed blood reveals genomic exchange events between Malaysian Peninsular and Borneo subpopulations. Sci Rep 9(1):9873. doi:10.1038/s41598-019-46398-z
He Y, Campino SG, Benavente ED, Warhurst D, Beshir K, Lubis I, Gomes AR, Feng J, Jiazhi W, Sun X, Huang F, Tang L, Sutherland C, Clark T (2019) Artemisinin resistance-associated markers in Plasmodium falciparum parasites from the China-Myanmar border: predicted structural stability of K13 propeller variants detected in a low-prevalence area. PLoS One 14:e0213686 . doi:10.1371/journal.pone.0213686
2018
Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A (2018) Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell 173:443-455.e12. doi:10.1016/j.cell.2018.02.047
Fang H*, Gomes AR*, Klages N*, Pino P, Maco B, Walker EM, Zenonos Z, Angrisano F, Baum J, Doerig C, Baker D, Billker O, Brochet M (2018) Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites. Nat Commun 9:4248. doi:10.1038/s41467-018-06733-w. *Co-first authorship
Andreadaki M, Hanssen E, Deligianni E, Claudet C, Wengelnik K, Mollard V, McFadden GI, Abkarian M, Braun-Breton C, Siden-Kiamos I (2018) Sequential Membrane Rupture and Vesiculation during Plasmodium berghei Gametocyte Egress from the Red Blood Cell. Sci Rep 8:3543. doi:10.1038/s41598-018-21801-3
Wein S, Ghezal S, Buré C, Maynadier M, Périgaud C, Vial HJ, Lefebvre-Tournier I, Wengelnik K, Cerdan R (2018) Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite. J Lipid Res 59:1461-1471. doi:10.1194/jlr.M085589
Guca E, Nagy GN, Hajdú F, Marton L, Izrael R, Hoh F, Yang Y, Vial H, Vértessy BG, Guichou JF, Cerdan R (2018) Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis. Sci Rep 8:11215. doi:10.1038/s41598-018-29500-9
Berry L, Chen CT, Francia ME, Guerin A, Graindorge A, Saliou JM, Grandmougin M, Wein S, Bechara C, Morlon-Guyot J, Bordat Y, Gubbels MJ, Lebrun M, Dubremetz JF, Daher W (2018) Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny. Cell Mol Life Sci 75:4417-4443. doi:10.1007/s00018-018-2889-6
Reid AJ*, Talman AM*, Bennett HM*, Gomes AR, Sanders MJ, Illingworth CJR, Billker O, Berriman M, Lawniczak MKN (2018) Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites. eLife 7:e33105. doi:10.7554/eLife.33105
2017
Wein S, Taudon N, Maynadier M, Tran Van Ba C, Margout D, Bordat Y, Fraisse L, Wengelnik K, Cerdan R, Bressolle-Gomeni F, Vial HJ (2017) High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death. Antimicrob Agents Chemother 61:e00352-17. doi:10.1128/AAC.00352-17
Gomes AR, Ravenhall M, Benavente ED, Talman A, Sutherland C, Roper C, Clark TG, Campino S (2017) Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes. Int J Parasitol Drugs Drug Resist 7:174-180. doi:10.1016/j.ijpddr.2017.03.001
Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM (2017) Nutrient sensing modulates malaria parasite virulence. Nature 547:213-216. doi:10.1038/nature2300
Modrzynska K, Pfander C, Chappell L, Yu L, Suarez C, Dundas K, Gomes AR, Goulding D, Rayner JC, Choudhary J, Billker O (2017) A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle. Cell Host Microbe 21:11-22. doi:10.1016/j.chom.2016.12.003
Dombrowski JG, Souza RM, Curry J, Hinton L, Silva NRM, Grignard L, Gonçalves LA, Gomes AR, Epiphanio S, Drakeley C, Huggett J, Clark TG, Campino S, Marinho CRF (2017) G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon. Malar J 16:253. doi:10.1186/s12936-017-1889-6
Francisco Hilario F, Traoré M, Zwick V, Berry L, Simões-Pires C, Cuendet M, Fantozzi N, Pereira de Freitas R, Maynadier M, Wein S, Vial H, Wong, YS (2017) Synthesis of an uncharged tetra-cyclopeptide acting as transmembrane carrier: enhanced cellular and nuclear uptake. Org Lett 19:612-615. doi:10.1021/acs.orglett.6b03776
Traoré MDM, Zwick V, Simões-Pires CA, Nurisso A, Issa M, Cuendet M, Maynadier M, Wein S, Vial H, Jamet H, Wong YS (2017) Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6. ACS Omega 2:1550-1562. doi:10.1021/acsomega.6b00481
Pegoraro S, Duffey M, Otto TD, Wang Y, Rösemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A, Mazier D, Vial HJ, Strobl S, Sanchez CP, Lanzer M (2017) SC83288 is a clinical development candidate for the treatment of severe malaria. Nat Commun 8:14193. doi:10.1038/ncomms14193
Bushell E*, Gomes AR*, Sanderson T*, Anar B, Girling G, Herd C, Metcalf T, Modrzynska K, Schwach F, Martin RE, Mather MW, McFadden GI, Parts L, Rutledge GG, Vaidya AB, Wengelnik K, Rayner JC, Billker O (2017) Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Cell 170, 260-272 e268. doi:10.1016/j.cell.2017.06.030. *Co-first authorship
2016
Daher W, Morlon-Guyot J, Alayi TD, Tomavo S, Wengelnik K, Lebrun M (2016) Identification of Toxoplasma TgPH1, a pleckstrin homology domain-containing protein that binds to the phosphoinositide PI(3,5)P2. Mol Biochem Parasitol 207:39-44. doi:10.1016/j.molbiopara.2016.03.011
Gomes AR, Talman AM (2016) Commitment issues in Plasmodium. Nat Rev Microbiol 14(1):4. doi:10.1038/nrmicro.2015.9
2015
Contet A, Pihan E, Lavigne M, Wengelnik K, Maheshwari S, Vial H, Douguet D, Cerdan R (2015) Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening. FEBS Letter 589:992-1000. doi:10.1016/j.febslet.2015.03.003
Gomes AR, Bushell E, Schwach F, Girling G, Anar B, Quail MA, Herd C, Pfander C, Modrzynska K, Rayner JC, Billker O (2015) A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite. Cell Host Microbe 17:404-13. doi:10.1016/j.chom.2015.01.014
Schwach F*, Bushell E*, Gomes AR, Anar B, Girling G, Herd C, Rayner JC, Billker O. “PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites”. Nucleic Acids Res (2015) Jan;43: D1176-82.
Winkler M, Maynadier M, Wein S, Lespinasse MA, Boumis G, Miele AE, Vial H, Wong YS (2015) Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives. Org Biomol Chem 13:2064-77. doi:10.1039/c4ob02459a
Daher W, Morlon-Guyot J, Sheiner L, Lentini G, Berry L, Tawk L, Dubremetz JF, Wengelnik K, Striepen B, Lebrun M (2015) Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol 17(4):559-78. doi:10.1111/cmi.12383