Publications - Équipe 2

2023

Mohamed BS, Nguyen MC, Wein S, Uttaro JP, Robert X, Violot S, Ballut L, Jugnarain V, Mathé C, Cerdan R, Aghajari N, Peyrottes S (2023) Purine containing carbonucleoside phosphonate analogues as novel chemotype for Plasmodium falciparum Inhibition. Eur J Med Chem 258:115581. doi:10.1016/j.ejmech.2023.115581

Lohia R, Allegrini B, Berry L, Guizouarn H, Cerdan R, Abkarian M, Douguet D, Honoré E, Wengelnik K (2023) Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion. Cell Mol Life Sci 80:124. doi:10.1007/s00018-023-04773-0

Ukegbu CV, Gomes AR, Giorgalli M, Campos M, Bailey AJ, Besson TRB, Billker O, Vlachou D, Christophides GK (2023) Identification of genes required for Plasmodium gametocyte-to-sporozoite development in the mosquito vector. Cell Host Microbe 31:1539-1551.e6. doi:10.1016/j.chom.2023.08.010

2022

Gomes AR, Marin-Menendez A, Adjalley S, Bardy C, Cassan C, Lee M, et al (2022) A transcriptional switch controls sex determination in Plasmodium falciparum. Nature 612:528-533. doi:10.1038/s41586-022-05509-z

Ward D, Gomes AR, Tetteh K, Sepulveda N, Gomez LF, Campino S, Clark TG (2022) Sero-epidemiological study of arbovirus infection following the 2015-2016 Zika virus outbreak in Cabo Verde. Sci Rep 12:11719. doi:10.1038/s41598-022-16115-4

2021

Gurung P, Gomes AR, Martins RM, Juranek SA, Alberti P, Mbang-Benet D, et al(2021) PfGBP2 is a novel G-quadruplex binding protein in Plasmodium falciparum. Cell Microbiol 23:e13303. doi:10.1111/cmi.13303

2020

Campos M, Ward D, Morales RF, Gomes AR, Silva K, Sepúlveda N, et al (2020) Surveillance des populations d'Aedes aegypti dans la ville de Praia, Cap-Vert : Infection par le virus Zika, résistance aux insecticides et diversité génétique. Parasit Vectors 13:481. doi:10.1186/s13071-020-04356-z

Gazanion E, Lacroix L, Alberti P, Gurung P, Wein S, Mergny JL, Gomes AR* et Lopez-Rubio JJ* (2020) Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites. PLoS Genet 16:e1008917. doi:10.1371/journal.pgen.1008917. *Coauteur principal

Cheviet T, Wein S, Bourchenin G, Lagacherie M, Périgaud C, Cerdan R*, Peyrottes S* (2020) β-Hydroxy- A et β-Aminophosphonate Acyclonucleosides as Potent Inhibitors of Plasmodium falciparum Growth. J Med Chem 63:8069-8087. doi:10.1021/acs.jmedchem.0c00131.*Coauteur principal

2019

Berger O, Ortial S, Wein S, Denoyelle S, Bressolle F, Durand T, Escale R, Vial HJ, Vo-Hoang Y (2019) Evaluation of amidoxime derivatives as prodrug candidates of potent bis-cationic antimalarials. Bioorg Med Chem Lett 29:2203-2207. doi:10.1016/j.bmcl.2019.06.045

Benavente ED, Gomes AR, Silva JR, Grigg MJ, Walker H, Barber B, William T, Yeo TW, Sessions PF, Ramaprasad A, Ibrahim A, Charleston J, ..., Campino SG, Clark T (2019) Whole genome sequencing of amplified Plasmodium knowlesi DNA from unprocessed blood reveals genomic exchange events between Malaysian Peninsular and Borneo subpopulations. Sci Rep 9(1):9873. doi:10.1038/s41598-019-46398-z

He Y, Campino SG, Benavente ED, Warhurst D, Beshir K, Lubis I, Gomes AR, Feng J, Jiazhi W, Sun X, Huang F, Tang L, Sutherland C, Clark T (2019) Artemisinin resistance-associated markers in Plasmodium falciparum parasites from the China-Myanmar border : predicted structural stability of K13 propeller variants detected in a low-prevalence area. PLoS One 14:e0213686 . doi:10.1371/journal.pone.0213686

2018

Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A (2018) Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell 173:443-455.e12. doi:10.1016/j.cell.2018.02.047

Fang H*, Gomes AR*, Klages N*, Pino P, Maco B, Walker EM, Zenonos Z, Angrisano F, Baum J, Doerig C, Baker D, Billker O, Brochet M (2018) Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites. Nat Commun 9:4248. doi:10.1038/s41467-018-06733-w. *Co-premier auteur

Andreadaki M, Hanssen E, Deligianni E, Claudet C, Wengelnik K, Mollard V, McFadden GI, Abkarian M, Braun-Breton C, Siden-Kiamos I (2018) Sequential Membrane Rupture and Vesiculation during Plasmodium berghei Gametocyte Egress from the Red Blood Cell. Sci Rep 8:3543. doi:10.1038/s41598-018-21801-3

Wein S, Ghezal S, Buré C, Maynadier M, Périgaud C, Vial HJ, Lefebvre-Tournier I, Wengelnik K, Cerdan R (2018) Contribution des précurseurs et interaction des voies dans le métabolisme des phospholipides du parasite du paludisme. J Lipid Res 59:1461-1471. doi:10.1194/jlr.M085589

Guca E, Nagy GN, Hajdú F, Marton L, Izrael R, Hoh F, Yang Y, Vial H, Vértessy BG, Guichou JF, Cerdan R (2018) Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis. Sci Rep 8:11215. doi:10.1038/s41598-018-29500-9

Berry L, Chen CT, Francia ME, Guerin A, Graindorge A, Saliou JM, Grandmougin M, Wein S, Bechara C, Morlon-Guyot J, Bordat Y, Gubbels MJ, Lebrun M, Dubremetz JF, Daher W (2018) Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle : a prerequisite for productive endodyogeny. Cell Mol Life Sci 75:4417-4443. doi:10.1007/s00018-018-2889-6

Reid AJ*, Talman AM*, Bennett HM*, Gomes AR, Sanders MJ, Illingworth CJR, Billker O, Berriman M, Lawniczak MKN (2018) Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites. eLife 7:e33105. doi:10.7554/eLife.33105

2017

Wein S, Taudon N, Maynadier M, Tran Van Ba C, Margout D, Bordat Y, Fraisse L, Wengelnik K, Cerdan R, Bressolle-Gomeni F, Vial HJ (2017) High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death. Antimicrob Agents Chemother 61:e00352-17. doi:10.1128/AAC.00352-17

Gomes AR, Ravenhall M, Benavente ED, Talman A, Sutherland C, Roper C, Clark TG, Campino S (2017) Genetic diversity of next generation antimalarial targets : Une base de référence pour les programmes de surveillance de la résistance aux médicaments. Int J Parasitol Drugs Drug Resist 7:174-180. doi:10.1016/j.ijpddr.2017.03.001

Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM (2017) Nutrient sensing modulates malaria parasite virulence. Nature 547:213-216. doi:10.1038/nature2300

Modrzynska K, Pfander C, Chappell L, Yu L, Suarez C, Dundas K, Gomes AR, Goulding D, Rayner JC, Choudhary J, Billker O (2017) A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle. Cell Host Microbe 21:11-22. doi:10.1016/j.chom.2016.12.003

Dombrowski JG, Souza RM, Curry J, Hinton L, Silva NRM, Grignard L, Gonçalves LA, Gomes AR, Epiphanio S, Drakeley C, Huggett J, Clark TG, Campino S, Marinho CRF (2017) Allèles de déficit en G6PD dans une région endémique du paludisme dans l'ouest de l'Amazonie brésilienne. Malar J 16:253. doi:10.1186/s12936-017-1889-6

Francisco Hilario F, Traoré M, Zwick V, Berry L, Simões-Pires C, Cuendet M, Fantozzi N, Pereira de Freitas R, Maynadier M, Wein S, Vial H, Wong, YS (2017) Synthèse d'un tétra-cyclopeptide non chargé agissant comme transporteur transmembranaire : absorption cellulaire et nucléaire améliorée. Org Lett 19:612-615. doi:10.1021/acs.orglett.6b03776

Traoré MDM, Zwick V, Simões-Pires CA, Nurisso A, Issa M, Cuendet M, Maynadier M, Wein S, Vial H, Jamet H, Wong YS (2017) Hydroxyl Ketone-Based Histone Deacetylase Inhibitors To Gain Insight into Class I HDAC Selectivity versus That of HDAC6. ACS Omega 2:1550-1562. doi:10.1021/acsomega.6b00481

Pegoraro S, Duffey M, Otto TD, Wang Y, Rösemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A, Mazier D, Vial HJ, Strobl S, Sanchez CP, Lanzer M (2017) SC83288 est un candidat au développement clinique pour le traitement du paludisme grave. Nat Commun 8:14193. doi:10.1038/ncomms14193

Bushell E*, Gomes AR*, Sanderson T*, Anar B, Girling G, Herd C, Metcalf T, Modrzynska K, Schwach F, Martin RE, Mather MW, McFadden GI, Parts L, Rutledge GG, Vaidya AB, Wengelnik K, Rayner JC, Billker O (2017) Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Cell 170, 260-272 e268. doi:10.1016/j.cell.2017.06.030. *Co-premier auteur

2016

Daher W, Morlon-Guyot J, Alayi TD, Tomavo S, Wengelnik K, Lebrun M (2016) Identification de Toxoplasma TgPH1, une protéine contenant un domaine d'homologie pleckstrine qui se lie au phosphoinositide PI(3,5)P2. Mol Biochem Parasitol 207:39-44. doi:10.1016/j.molbiopara.2016.03.011

Gomes AR, Talman AM (2016) Commitment issues in Plasmodium. Nat Rev Microbiol 14(1):4. doi:10.1038/nrmicro.2015.9

2015

Contet A, Pihan E, Lavigne M, Wengelnik K, Maheshwari S, Vial H, Douguet D, Cerdan R (2015) Plasmodium falciparum CTP:phosphocholine cytidyltransferase possède deux domaines catalytiques fonctionnels et est inhibée par un analogue de CDP-choline sélectionné à partir d'un criblage virtuel. FEBS Letter 589:992-1000. doi:10.1016/j.febslet.2015.03.003

Gomes AR, Bushell E, Schwach F, Girling G, Anar B, Quail MA, Herd C, Pfander C, Modrzynska K, Rayner JC, Billker O (2015) A genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite. Cell Host Microbe 17:404-13. doi:10.1016/j.chom.2015.01.014

Schwach F*, Bushell E*, Gomes AR, Anar B, Girling G, Herd C, Rayner JC, Billker O. "PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites". Nucleic Acids Res (2015) Jan;43 : D1176-82.

Winkler M, Maynadier M, Wein S, Lespinasse MA, Boumis G, Miele AE, Vial H, Wong YS (2015) Uncovering new structural insights for antimalarial activity from cost-effective aculeatin-like derivatives. Org Biomol Chem 13:2064-77. doi:10.1039/c4ob02459a

Daher W, Morlon-Guyot J, Sheiner L, Lentini G, Berry L, Tawk L, Dubremetz JF, Wengelnik K, Striepen B, Lebrun M (2015) Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol 17(4):559-78. doi:10.1111/cmi.12383