Publications – Group S. Besteiro

For a complete overview of the publications of the group, click here

Recent publications

Renaud EA, Maupin AJM, Berry L, Bals J, Bordat Y, Demolombe V, Rofidal V, Vignols F, Besteiro S. The HCF101 protein is an important component of the cytosolic iron-sulfur synthesis pathway in Toxoplasma gondii. PLoS Biol. 23(2):e3003028. doi: 10.1371/journal.pbio.3003028

Sanchez SG, Pouzet E, Guimbaud L, Graindorge A, Berry L, Besteiro S. (2025) TgGloL is an atypical glyoxalase/VOC domain-containing apicoplast protein that is important for the growth of Toxoplasma. Mol Biol Cell. 36(3):ar32. doi: 10.1091/mbc.E24-09-0391

Renaud EA, Maupin AJM, Besteiro S.Iron‑sulfur cluster biogenesis and function in Apicomplexa parasites. (2025) Biochim Biophys Acta Mol Cell Res. 1872(1):119876. doi: 10.1016/j.bbamcr.2024.119876 Review

Dupouy B, Donzel M, Roignant M, Charital S, Keumoe R, Yamaryo-Botté Y, Feckler A, Bundschuh M, Bordat Y, Rottmann M, Mäser P, Botté CY, Blandin SA, Besteiro S, Davioud-Charvet E. (2024) 3-Benzylmenadiones and their Heteroaromatic Analogues Target the Apicoplast of Apicomplexa Parasites: Synthesis and Bioimaging Studies. ACS Infect Dis. 11;10(10):3553-3576. doi: 10.1021/acsinfecdis.4c00304

Maclean AE, Sloan MA, Renaud EA, Argyle BE, Lewis WH, Ovciarikova J, Demolombe V, Waller RF, Besteiro S, Sheiner L. (2024) The Toxoplasma gondii mitochondrial transporter ABCB7L is essential for the biogenesis of cytosolic and nuclear iron-sulfur cluster proteins and cytosolic translation. mBio. 15(10):e0087224. doi: 10.1128/mbio.00872-24

Renaud EA, Maupin AJM, Bordat Y, Graindorge A, Berry L, Besteiro S. (2024) Iron depletion has different consequences on the growth and survival of Toxoplasma gondii strains.Virulence (1):2329566.doi: 10.1080/21505594.2024.2329566

Sanchez SG, Bassot E, Cerutti A, Mai Nguyen H, Aïda A, Blanchard N, Besteiro S (2023) The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoites. Proc Natl Acad Sci USA 120:e2309043120. doi:10.1073/pnas.2309043120

Romano PS, Akematsu T, Besteiro S, Bindschedler A, Carruthers VB, Chahine Z, Coppens I, Descoteaux A, Alberto Duque TL, He CY, Heussler V, Le Roch KG, Li FJ, de Menezes JPB, Menna-Barreto RFS, Mottram JC, Schmuckli-Maurer J, Turk B, Tavares Veras PS, Salassa BN, Vanrell MC (2023) Autophagy in protists and their hosts: When, how and why? Autophagy Rep 2:2149211. doi:10.1080/27694127.2022.2149211

Walczak M, Meister TR, Nguyen HM, Zhu Y, Besteiro S, Yeh E (2023) Structure-Function Relationship for a Divergent Atg8 Protein Required for a Nonautophagic Function in Apicomplexan Parasites. mBio 14:e0364221. doi:10.1128/mbio.03642-21

Renaud EA, Pamukcu S, Cerutti A, Berry L, Lemaire-Vieille C, Yamaryo-Botté Y, Botté CY, Besteiro S (2022) Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability. J Biol Chem 298:102243. doi:10.1016/j.jbc.2022.102243

Sanchez SG, Besteiro S (2021) The pathogenicity and virulence of Toxoplasma gondii. Virulence 12:3095-3114. doi:10.1080/21505594.2021.2012346

Pamukcu S, Cerutti A, Bordat Y, Hem S, Rofidal V, Besteiro S (2021) Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in Toxoplasma. PLoS Pathog 17:e1010096. doi:10.1371/journal.ppat.1010096

Hamie M, Tawil N, El Hajj R, Najm R, Moodad S, Hleihel R, Karam M, El Sayyed S, Besteiro S, El-Sabban M, Dubremetz JF, Lebrun M, El Hajj H (2021) P18 (SRS35/TgSAG4) Plays a Role in the Invasion and Virulence of Toxoplasma gondii. Front Immunol 12:643292. doi:10.3389/fimmu.2021.643292

Sakamoto H, Nakada-Tsukui K, Besteiro S (2021) The Autophagy Machinery in Human-Parasitic Protists; Diverse Functions for Universally Conserved Proteins. Cells 10:1258. doi:10.3390/cells10051258

Smith D, Kannan G, Coppens I, Wang F, Nguyen HM, Cerutti A, Olafsson EB, Rimple PA, Schultz TL, Mercado Soto NM, Di Cristina M, Besteiro S, Carruthers VB (2021) Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts. Elife 10:e59384. doi:10.7554/eLife.59384