ATIP Team / Post-transcriptional Regulation of Gene Expression in P. falciparum

HEAD OF THE TEAM

Dr. Thomas Hollin

RESEARCH INTERESTS

We are an ATIP-Avenir team exploring the mechanisms of gene regulation in the human malaria parasite, Plasmodium falciparum.

This parasite possesses the ability to convert in multiple stages in various cell types in two different hosts. In response to these different environmental conditions, the parasite acquires elaborated and complementary layers of mechanisms controlling gene expression to ensure its survival, spread and transmission. Despite their importance, these mechanisms are largely unknown and remain an important knowledge gap.

Our research primarily focuses on identifying and understanding RNA-binding proteins and mechanisms regulating gene expression at the post-transcriptional level in P. falciparum. We investigate these mechanisms using a range of complementary approaches, including molecular biology, next-generation sequencing technologies, and proteomics.